The name Living Brain may pertain to any of the following:
- Living Brain - an artificial intelligence created by Dr. Petty to serve as problem solving tool that has been misused by many individuals over the years as an accomplice in their criminal endeavors
- Otto Octavius - a former adversary of Spider-Man's who consciousness currently inhabits the Living Brain's body.
- Living Brain - an artificial intelligence created by the Roxxon corporation whose purpose was to deduce Spider-Man's secret identity.
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